Why combine protein function and modification? There’s a reason so many study sites have flashcard features, and it’s not just because they’re easy to program. I think textbooks and lecture can create the impression that introductory biology is nothing but a steady stream of equally-weighted, isolated terms and ‘things’. By finding and teaching relationships, we not only make big concepts easier to see and grasp, we increase the likelihood that they’ll stick and that students will feel a growing sense of power in their grasp of course material. This post will cover a unit that I think ties together a concrete example of enzyme function (ATPase), environmental effects and mechanism of pH (which is further explored in another thematic collection here), and protein control via phosphorylation (which, intriguingly, is achieved through a mechanism related to… ATPase chemistry!).
Too often, we seem to act as if first year biology students aren’t ‘smart enough’ to understand things and that it would be ‘easier’ if we just told them the names of things and the order in which they operate. This matches up with no modern model of learning and assumes some magical transformation happens during their sophomore year. Instead, I think we should start them on a diet rich in concepts and unifying themes and ideas. In this first post of what I hope will be a series, I’ll lay out what I think the Big, teachable ideas in the biological process of translation are.
If you’ve explored the site before, I wanted to provide some updates on things that are newly installed, things that work better, and the Big Thing that I hope to drop on Wed. or Thu. of this week
The three things I learned in college:1) I am [expletive]2) Everyone else is [expletive]3) Mitochondria is the powerhouse of the cell
Sean Carroll’s ‘The Making of the Fittest‘ shows up in a number of reference lists for thinkBio; the reason is that he’s put together a wonderful compendium of topics that can make for a compelling Introductory Biology experience. They’re basically molecules whose evolutionary history and roles are interesting and well-understood. The book packages them into interesting units, and also provides a wealth of resources for an instructor wishing to make sure he/she has a sound background in the material being taught.
Many institutions divide Introductory Biology into Cell/Molecular and Ecology/Evolution semesters. There is some sense to this, in that one scale can be seen as cellular and smaller, the other organismal and larger. However, failing to weave the influences, evidences and implications of evolution into the cell-molecular semester wastes an opportunity to show students through our teaching of these topics how central these ideas are. Further, there are a wonderful molecular examples that represent powerful, approachable proofs and demonstrate to students what they can do if they pick up these tools.