Author: Bruce

  • What’s important about… biology’s Central Dogma?

    What’s important about… biology’s Central Dogma?

    ‘What to teach’ in Introductory Biology presents a whole host of conundrums. Is our role to cover the breadth of all of biology (or all of the biology student will hear again in upper divisions) at breakneck pace and without depth? A whirlwind tour of vocabulary to commit to memory with vague understanding for some later date? I will argue periodically that we should pick a limited, integrated fraction of possible content and teach it in a way that allows students to see and grasp underlying concepts and universal themes, thereby enabling them to figure out what comes later, and to embark on their own to investigate whatever catches their fancy.Ribosomes translating mRNA

    The key ideas of biology’s Central Dogma–or better put, the flow of information— are a critical case in point. We all agree that ‘something’ about DNA, RNA and protein is among our core duties. But what? My view is that identifying the roles of each of these players, how their structures fit them to play those roles, how they came to occupy and the ‘flow’ between them them are straightforward, core ideas in biology.

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  • What’s important about… the TCA Cycle

    What’s important about… the TCA Cycle

    The Kreb’s cycle/TCA cycle/Citric acid cycle is a cornerstone of most introductory biology discussions of energetics. Boy is it scary to look at, but what a wonderful opportunity to make students memorize names and structures! But seriously… short of asking students to know everything about everything, what are the core concepts that they ‘ought’ to understand?

    To my mind, two words: energetic electrons

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  • New Lecture Components

    I’ve made a first stab at adding some lecture component materials (stuff I’ve already researched and collated; note that many of these could be used an in-class exercises or at-home student explorations). These are meant to be collections of inter actives (often simulations or explorations I’ve created), Web and literature resources, and sometimes Powerpoint/Keynotes files and movies from my own lectures.

    Yesterday, I made a first pass at Opsin; this joins existing Flu and Cytosine/Uracil/Thymine modules; I also added a bit to the Blue eyes vs. Lactose intolerance set (where we deduce number and timing of origin of human mutations from gene sequence comparison). All are accessible from the link above.

  • Problem-Solving Strategies II: Stuff I say

    Over the years, I’ve developed a number of questions/suggestions I often use in assisting students in the development of new problem-solving strategies. The goal is to guide students find strategies for approaching novel problems (the good kind, where you aren’t just adjusting for different values, but are really trying to figure out something ‘new’).  (more…)

  • Problem-Solving Strategies I: Polya

    We all want our students to ‘think critically’ and ‘become better problem solvers’. But what does that mean, and how do we scaffold and provide opportunities developing problem-solving strategies? Obviously, this question is deeper and wider than a single blog post, but I wanted to put my first card on the table. First and foremost, this must all begin with ‘legitimate’ problems. To me, this means ones where a student must reach beyond plug-and-play; there must be elements of identifying which information is useful, choosing approaches that attack weak points of the problem, finding their own path rather than following ones already mapped out. Two cases that I think exemplify ‘real’ problems are Petals around the rose and (surprise surprise) my own PatternMaster.

    The rest of this introductory post is dedicated to a distillation of George Polya’s advice to young mathematicians

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  • Flu virus: pH, organelles, proteins, drugs

    Flu virus: pH, organelles, proteins, drugs

    Contagious Disease InfectionIntegrating major course ideas into coherent themes is a big deal for me. I introduced the topic here. One that I really enjoy is  teaching biology with the flu virus (follow the link for resources associated with discussion below).  Briefly, influenza attaches to the surface of your cells through specific interactions, is internalized, and then all hell breaks loose when you pump protons into the resulting vesicle. You’re trying to digest it. Its waiting for a sign it’s inside.

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